Dr. Andrew Huberman discusses how the antidepressant effects of ketamine are influenced by its interaction with the opioid system, highlighting a Stanford study that shows blocking opioid receptors with naltrexone diminishes ketamine's antidepressant efficacy.

Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine and host of the Huberman Lab podcast.

Watch the full episode on YouTube:    • Ketamine: Benefits and Risks for Depr...  
Show notes: https://www.hubermanlab.com/episode/k...
Attenuation of Antidepressant Effects of Ketamine by Opioid Receptor Antagonism (The American Journal of Psychiatry): https://bit.ly/48dEAqT

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Timestamps
00:00 Introduction to the Opioid Crisis
00:32 Understanding Opioid Receptors
00:59 Ketamine & Its Effects
01:32 Clinical Studies on Ketamine
02:54 The Role of Hydroxynorketamine
03:52 Opioid System's Impact on Depression Relief
04:31 Key Study on Ketamine & Naltrexone
06:22 Implications for Psychiatric Treatment
07:32 Concluding Thoughts on Drug Effects

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