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Bradykinin (Greek brady-, slow; -kinin, kīn(eîn) to move) is an inflammatory mediator. It is a peptide that causes blood vessels to dilate (enlarge) via the release of prostacyclin, nitric oxide, and Endothelium-Derived Hyperpolarizing Factor. Bradykinin is a physiologically and pharmacologically active peptide of the kinin group of proteins, consisting of nine amino acids.

A class of drugs called angiotensin-converting enzyme (ACE) inhibitors increase bradykinin levels by inhibiting its degradation, thereby increasing its blood pressure-lowering effect. ACE inhibitors are FDA approved for the treatment of hypertension and heart failure.

Bradykinin is a potent endothelium-dependent vasodilator and a mild diuretic, which may cause a lowering of the blood pressure. It also causes contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain.

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