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Autacoids or "autocoids" are biological factors (molecules) which act as local hormones, have a brief duration, and act near their site of synthesis. The word autacoid comes from the Greek "autos" (self) and "Ecos" (relief; i.e., drug)

Although these are a local hormone, they do not have a characteristic feature of hormones-

Autocrine – Histamine, Prostaglandins, Serotonin Paracrine – Nitric Oxide (NO), Endothelin-1 (ET-1)
Histamine in the body stored in mast cells (present in the gut and lungs) and basophils and Plays a role in allergic/hypersensitivity reactions
(via activation of H1 receptors) other action
(1) In neurons in the CNS and peripheral nerves (H1)
(2) Plays a role as a Neurotransmitter/Neuromodulator
(3) Stimulates gastric acid secretion (via H2 receptors)

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