Published On Jan 1, 2023
Organic chemistry does not only use abundant forms of atoms but also rare isotopes such as deuterium - the heavy form of hydrogen. Addition of "the D" can completely transform a molecule's reactivity and pharmacokinetic properties. Watch this to find out more about the physical chemistry, biochemistry and organic synthesis associated with Deuterium and more specifically, the discovery route and large-scale process behind the second deuterated drug to be approved by the US FDA, deucravacitinib (Sotyktu).
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00:00 Why you should care about D
01:40 Deuterium's discovery and application in medicinal chemistry (deutetrabenazine)
06:44 Psoriasis landscape, key molecules and mechanisms of action
09:08 Deucravacitinib Tyk 2 deep dive and outlook
12:33 Discovery chemistry route overview
14:54 Process chemistry route deep dive
Main paper: Development of a Commercial Process for Deucravacitinib, a Deuterated API for TYK2 Inhibition; https://pubs.acs.org/doi/10.1021/acs....
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165; https://pubs.acs.org/doi/abs/10.1021/...
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No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube.
Some recommended books on organic synthesis:
Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge)
Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis)
Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions)
Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy)
Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life)
Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)
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