Jimmy Carr hosts as celebrity quizzers James Corden, Sean Lock, Claudia Winkleman, Davina McCall, Michael McIntyre, and Dara O'Briain go head to head.

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A special edition of the show, celebrating Channel 4's 25th anniversary, was broadcast on 2 November 2007. Carr and Dee emerged victorious at the climax, and so had to take part in a special challenge that replicated the finale of The Crystal Maze. The pair had to collect silver and gold pieces of paper being blown around in a glass dome.

Vic Reeves and Joanna Fisher, who was a member of the 1980s Channel 4 programme Minipops both came into the studio to ask bonus questions. Jon Snow read out a fake news report on The Snowman. Quentin Tarantino, Anna Friel, Jonathan Ross, Ram John Holder, Derren Brown, Jo Frost, Jools Holland and others appeared on pre-recorded filmed questions. The children of Mitchell Brook Primary school acted out classic Channel 4 programmes The Word and TFI Friday.

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