Writer/Director Coralie Fargeat's Cannes-winning body-horror blitz THE SUBSTANCE features Demi Moore as an aging star who turns to a mystery drug in hopes of becoming a better, younger version of herself. Fargeat tells host Rico Gagliano about casting Moore, why blood and guts are great metaphors, and the pain of makeup removal.

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THE SUBSTANCE is now showing in theaters across the US, UK, Latin America, Germany, Canada, and The Netherlands.

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Originally released Thursday September 19th