Sho Yano entered college at Loyola University of Chicago at age 9. After receiving a Bachelor of Science in Biology at age 12, he entered the M.D/Ph.D program at the University of Chicago Pritzker School of Medicine. He received a Ph.D. in Molecular Genetics and Cell Biology at age 18 and an M.D. at age 21. He trained in pediatrics and in neurology at the University of Chicago Hospitals and completed a medical genetics fellowship through the National Institutes of Health/Johns Hopkins Hospital consortium training program. Presently, he is board certified in three medical specialties (pediatrics, child neurology, and medical genetics).