Cystic fibrosis-related diabetes (CFRD) is an increasingly prevalent condition, affecting up to a quarter of adolescents and half of adults with CF, and often poses significant health challenges. The primary defect underlying CFRD is the pancreatic beta cell's inability to secrete sufficient insulin to maintain normal blood glucose levels. Despite recent advances in our understanding of the pancreatic processes that may contribute to beta cell dysfunction, we have much to learn about why CFRD develops and how to prevent it. Additionally, as the CF population ages and undergoes pulmonary and nutritional improvements — alongside rising obesity rates — the landscape of CFRD is evolving.

During plenary 2 of the North American Cystic Fibrosis Conference, speakers focus on recent advances and exciting new directions in basic science and clinical research in the field of CFRD. Rebecca Hull-Meichle, PhD, gives us a view of the CF pancreas under a microscope, focusing on new insights into cellular mechanisms underlying CFRD and how these discoveries may one day be translated into potential therapies. Melissa Putman, MD, takes us through the changing landscape of CFRD in the post-modulator era, including emerging diabetes technologies, new treatment strategies, and redefining nutrition in an aging CF population.  

Livestreamed from NACFC 2024 in Boston, Massachusetts September 26, 2024.