We know that NSAIDs can inhibit both COX-1 and COX-2 enzymes. But these enzymes perform slightly different functions, and it seems that inhibition of COX-2 leads to the beneficial affects of NSAIDs while inhibition of COX-1 leads to the unwanted side effects. Well what if we could take advantage of slight discrepancies in the two active sites to inhibit only one enzyme and not the other? In fact it's been done! However, so far the results are not as promising as hoped. In fact, one such drug, Vioxx, was the subject of the largest drug recall in history. Let's get a closer look at this and other COX-2 selective inhibitors.

Script by Chris Hofmann

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