Your thymus isn't talked about much, but this small organ in your upper chest is a key component of your immune system that is solely responsible for the essential "education" of the immune cells that protect your body from invaders. Through this action it also affects levels of inflammation (an immune-mediated process). It's also interesting to note that most of us end up dying of an immune-related dysfunction - even cardiovascular disease, as Dr. Greg Fahy points out in this New Frontiers podcast, is often caused by atherosclerosis driven by underlying chronic inflammation.

I was thrilled to finally sit down with Dr. Fahy, whose groundbreaking work in aging has truly reshaped our understanding of what’s possible. His 2019 TRIIM study, showing clear epigenetic age reversal through thymus regeneration, was an absolute game-changer. The thinking prior to that was that epigenetic age reversal was not possible! It was exciting to read his publication as we were in the midst of our own original clinical trial. I'm sure you'll enjoy his recounting of that adventure and just how he's rejuvenating thymic function, the rationale for targeting immune rejuvenation, and the trial extensions he's currently working on now, in this episode of New Frontiers. - DrKF

Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. ~DrKF

GUEST DETAILS
Greg Fahy, PhD
Chief Scientific Officer and Co-founder Intervene Immune
Email: [email protected]

Dr. Greg Fahy received his Ph.D. in Pharmacology and Cryobiology from the Medical College of Georgia in 1977. A world-renowned cryobiologist, Dr. Fahy is the chief science officer and co-founder of Intervene Immune, where he leads groundbreaking research on thymus regeneration and combating age-related immune decline. He designed and led the TRIIM trial, the first to demonstrate both thymus rejuvenation and the reversal of human epigenetic age. His work has been pivotal in advancing aging research, resulting in successful follow-up trials like TRIIM-XA, and further planned studies aimed at refining and expanding these innovative treatments.

THANK YOU TO OUR SPONSOR
DIAMOND
Rupa Health: https://tinyurl.com/4anbz7b3
Biotics Research: https://www.bioticsresearch.com/
Integrative Therapeutics: https://tinyurl.com/4emwj48z

GOLD
OneSkin: https://tinyurl.com/ycxtw4zt
TimeLine Nutrition:: https://tinyurl.com/bdzx2xms

MIDROLL
OneSkin: https://tinyurl.com/ycxtw4zt
DUTCH https://dutchtest.com/

SHOW NOTES
Intervene Immune https://interveneimmune.com/

Reversal of epigenetic aging and immunosenescent trends in humans https://tinyurl.com/55dhx453

TRIIM-X Trial: Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial https://tinyurl.com/y65cu33p

The Future of Aging: Pathways to Human Life Extension https://tinyurl.com/3hmbx29c

Steve Horvath, PhD, ScD https://tinyurl.com/3f4jww7j

Bobby Brooke https://tinyurl.com/3f4jww7j

Science: TRIIM trial to target thymus https://tinyurl.com/4s79zkzv

Nature: First hint that body’s ‘biological age’ can be reversed https://tinyurl.com/nfz9ruy7

Research and Resources from Intervene Immune https://tinyurl.com/ymu2ffat

TAME Trial https://tinyurl.com/yc3ce32b

Study: Apparent induction of partial thymic regeneration in a normal human subject: a case report
Apparent induction of partial thymic regeneration in a normal human subject: a case report https://tinyurl.com/yt7b8484

Study: Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

Can people with type 2 diabetes live longer than those without? A comparison of mortality… https://tinyurl.com/4thfsrrr

NEW FRONTIERS RESOURCES
Blog: New and Notable Studies Using Epigenetic Biological Age Clocks

Podcast: Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano

Podcast: AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price

Interview: Past, Present, and Future of “Biological Aging” with Dr. Fitzgerald

CONNECT WITH DrKF
Facebook:   / drkarafitzgerald  
YouTube: https://tinyurl.com/hjpc8daz
Instagram:   / drkarafitzgerald  

DrKF Clinic: Patient consults with DrKF physicians https://tinyurl.com/yx4fjhkb
Bio Age Lab Test: https://tinyurl.com/b7bjmfj9
Bio Age Self Assessment Quiz: https://tinyurl.com/4z8f7ucc
Younger You Group Program: https://tinyurl.com/4hvusavw
Younger You book: https://tinyurl.com/mr4d9tym
Better Broths and Healing Tonics book: https://tinyurl.com/3644mrfw