Uncharted 4: A Thief's End is an action-adventure video game developed by Naughty Dog and published by Sony Computer Entertainment. It is the fourth main entry in the Uncharted series, and was released in May 2016 for PlayStation 4. The single-player story follows Nathan Drake, a former treasure hunter, who is coaxed out of retirement by estranged older brother Sam to search for Henry Avery's lost treasure, whilst battling a mercenary group led by Rafe Adler and Nadine Ross, who are also after the treasure. The game is the last in the series to feature Nathan Drake.

The game's world is navigated on foot or by vehicle, and players are required to use Drake's platforming abilities to progress the story, which also features puzzle sequences, while many missions involve shooting and combat gameplay. It is played through a third-person perspective. Uncharted 4: A Thief's End also contain a rewards system for completing certain objectives.

Development was hampered significantly in 2014, after lead writers and creative directors Amy Hennig and Justin Richmond departed Naughty Dog. They were replaced by Bruce Straley and Neil Druckmann, who had directed the company's previous game, The Last of Us, and many elements were scrapped or redesigned. The development team sought to incorporate elements of open-world gameplay, with vehicles and larger levels. Stealth play was also made more realistic, and multiplayer was upgraded with competitive and co-operative modes.

Uncharted 4: A Thief's End received praise for its narrative, emotional depth, musical score, visual quality, improved gameplay, and multiplayer modes. Several reviewers found the game a worthy conclusion to Drake's story arc, and it won Game of the Year awards from several gaming publications and award events. It quickly became the highest-selling game in the series, and is the best-selling PlayStation 4 game. A standalone expansion, The Lost Legacy, was released in 2017.