Wythenshawe Hall is a 16th-century timber-framed historic house and former manor house in Wythenshawe, Manchester, England, five miles (8 km) south of Manchester city centre in Wythenshawe Park. Built for Robert Tatton, it was home to the Tatton family for almost 400 years. Its basic plan is a central hall with two projecting wings.

Rebuilding work was carried out at the end of the 18th century, and various additions made in the 19th century, including a walled garden, an ice house, glass houses and a tenant's hall. Wythenshawe Hall and its surrounding parkland were donated to Manchester Corporation in 1926, and in 1930 it was opened to the public as a museum.

The building was badly damaged in an arson attack in March 2016; the hall finally reopened to visitors in September 2022 after extensive repairs.