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According to what I have read, learned, and experienced over the past years and also my personal opinion, the standard and the most effective dosage for the metronidazole, especially in a discus tank is 250 mg per 10 gallons of water every other day for up to 4 days with at least 50% water change before each dose. Keep in mind that at least a minimum of 3 doses is necessary to eliminate the newly hatched larvae of the parasites and that is because the eggs from parasites are not affected by Noritate; So that, although most of the live parasites will die rapidly right after the first dose of the medicine, the parasites eggs will be hatched couple of hours later.