The Doctor, realising they have one chance, uses Gadget to roll across the Mars landscape and bring the TARDIS to the base.
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As time runs out, the infected personnel begin to scream, adding their efforts to the Flood's release. Just as the Flood begins to escape the glacier, the TARDIS materialises in the control room, and the survivors get inside. The nuclear device explodes, destroying the base and wiping out all the Flood creatures, the explosion unnoticeable from Mars' atmosphere.

Taken from Doctor Who Series 4.

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