Panaca is an unincorporated town in eastern Lincoln County, Nevada, United States, on State Route 319, about 1 mile (1.6 kilometers) east of U.S. Route 93, near the border with Utah. Its elevation is 4,729 feet (1,441 meters) above sea level. As of the 2010 census, it had a population of 963. It is one of only two cities in Nevada that prohibits gambling, the other being Boulder City.
Panaca was southern Nevada's first permanent settlement, founded as a Mormon colony in 1864. It was originally part of Washington County, Utah, but the congressional redrawing of boundaries in 1866 shifted Panaca into Nevada. It is the only community in Nevada to be "dry" (forbidding the sale of alcoholic beverages), and the only community in Nevada, besides Boulder City, that prohibits gambling.

Coke ovens here once produced charcoal for the smelters in nearby Bullionville (now a ghost town), but the town's economy is predominantly agricultural.

The name "Panaca" comes from the Southern Paiute word Pan-nuk-ker, which means "metal, money, wealth". William Hamblin, a Mormon missionary to the Paiutes, established the Panacker Ledge (Panaca Claim) silver mine there in 1864.