IMPORTANT –– Before watching, please watch Dr. Budoff's initial Match Analysis presentation from CoSci here:    • Match Analysis of High LDL on Keto – ...  

In this video, Dave Feldman, Adrian Soto and Nick Norwitz review preliminary data comparing high LDL cholesterol levels in individuals on a ketogenic diet to a Miami Heart study cohort. They discuss key findings from plaque scans, LDL particle count, small dense LDL particles, and the lipid energy model. They emphasize the need for more data while also reflecting on surprising differences between the two populations in terms of lipid profiles and plaque burden.

Chapter List:
0:00 Introduction to Preliminary Data
0:37 Explanation of Plaque Scoring System
1:24 Dr. Budoff’s Presentation Overview
1:56 Total Plaque Score vs. Lipid Metrics
3:10 Discussion on LDL Cholesterol Correlation
5:00 Different Populations, Different Outcomes
6:13 LDL Correlation in Miami Heart vs. Keto Group
7:46 Nick Norwitz on LDL and Plaque Progression
9:24 The Role of Triglycerides and HDL
12:03 Lean Mass Hyper-Responders (LMHRs) and Their Unique Profile
14:02 Contextualizing HDL and LDL Numbers in LMHRs
16:00 Evaluating Standard Lipid Panel Results
19:09 Total Plaque Score vs. LDL Particle Count
22:09 The Importance of Particle Count vs. Cholesterol
26:00 Total Plaque Score vs. Small Dense LDL
29:12 The Role of Flux and Delivery in Lipid Energy Model
33:00 Total Plaque Score vs. Lp(a)
39:00 Thoughts on Inflammation and Lp(a)
44:00 Total Plaque Score vs. Oxidized Phospholipids
48:00 AI-Guided Reading of CT Scans
50:35 Comparison of Non-Calcified Plaque Volume
53:14 Excluding Cholesterol-Lowering Medications
56:30 Closing Thoughts on Lipid Energy Model and Future Studies