A large number of medications have been reported to trigger onset of classic systemic sclerosis or localized scleroderma (morphea). Anticancer (chemotherapy) drugs, the largest class, will be discussed as they are of special interest to systemic sclerosis patients. Other types of drugs reported to induce scleroderma such as migraine headaches drugs, vitamin B1 and B12 injections, and oral contraceptive agents will also be discussed.


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