I could only put Shredder next to Megatron. In my opinion two of the most iconic cartoon villains. In particular, TFP and TMNT 2012 were the first series with which I approached these franchises. Shredder is certainly a powerful and menacing enemy who has created psychological and physical wounds to all the turtles but also to Splinter. I wasn't thrilled with the idea of him becoming a mutant in the final stage, but on this show literally everyone gets mutated at one point or another XD.
Song: Crossed The Line
Artist: No Resolve
Scenes: Teenage Mutant Ninja Turtles 2012