One method I use to animate my characters faces using just a 2D texture and some shader work within blender!

Here's another great method if you have multiple textures:
   • 2D Facial Rigs Just got 10x EASIER in...  

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CelesTools - Easily add cute details to your Blender art!
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// Timestamps
0:00 Intro
0:31 Setup
1:34 Face Unwrapping
2:16 UV Grid Explained
2:45 Exporting Textures
3:08 Texturing in CSP
5:49 Shader Setup
8:40 Control using Drivers
11:20 Separate Eye and Mouth Control
12:22 Outro

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