Amritha Express is a overnight express train operated by the Southern Railway zone of the Indian Railways between Thiruvananthapuram Central in Kerala, and Madurai Junction in Tamil Nadu

It was introduced in January 2001 by the then Railway Minister O. Rajagopal, from Thiruvananthapuram Central to Palakkad Town. This train is named after Mata Amritanandamayi, a well known spiritual leader. At first, the train used to run between Thiruvananthapuram Central to Palakkad, then extended up to Pollachi later extended to Madurai Junction. It starts from Thiruvananthapuram Central, runs via Kollam Junction, Kayamkulam Junction, Tiruvalla, Changanasseri, Kottayam, Ernakulam Town, Aluva, Thrissur, Ottapalam, Palakkad Junction, Kollengode, Pollachi Junction, Udumalaipettai, Palani, Dindigul Junction, then reaches Madurai Junction the next day.