Serotonin is an extremely powerful molecule, and it's the target for many therapeutic and recreational drugs. Understanding serotonin's story -- how it's made, stored, released, how it activates a postsynaptic cell, how it is removed from the synapse and how it is reused and recycled -- will help you to understand many of the pharmacological manipulations we have for this amazing monoamine. Ready to get happy? Let's unpack serotonin together.

#physiology #nursingstudent #neurotransmitters #serotonin #psychedelic #antidepressant

CORRECTION
*In the structure of MDMA shown in the video, there is a methyl missing alpha with respect to the nitrogen, but it's not part of the pharmacophore.*

Disclaimer
Penguin Prof videos are produced for informational and educational purposes only, and they not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition.

Chapters:
Intro: 0:00
The brain on serotonin: 0:20
Neuron review: 1:09
Six steps of the serotonin story: 1:30
Step 1: Synthesis: 2:05
Step 2: Storage: 2:26
Step 3: Release: 2:39
Step 4: Postsynaptic cell activation: 2:42
Step 5: Clearing: 3:19
Step 6: Reuse and breakdown: 3:58
Intro to pharmacological manipulation (how the drugs work): 4:31
MAOIs: 5:20
Marplan, Nardil, Ensam, Parnate
Serotonin reuptake inhibitors: 5:41
SSRIs vs. SNRIs: 6:00
SSRIs: Celexa, Lexapro, Prozac, Luvox, Paxil, Zoloft, Priligy
SNRIs: Khedezla, Pristiq, Cymbalta, Drizalma, Irenka, Fetzima, Savella, Effexor
Serotonin agonists: LSD and psilocybin (magic mushrooms): 6:49
More magic - pharmacophores: 7:08
Ecstasy (MDMA): 7:34
Self-quiz: 8:28
Review: 8:36
Outro: 9:04

Penguin Proff Staff:
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